Key result
Left ventricular hypertrophy in patients with uncomplicated essential hypertension was associated with significantly elevated sVCAM-1 levels (984.4 vs 759.7 ng/mL, P<0.0001).
Why the study?
Does sVCAM-1 correlate with left ventricular mass in outpatients with uncomplicated essential hypertension?
Population
80 outpatients with uncomplicated essential hypertension
Comparison
Measurement of plasma levels of soluble… vs Patients without left ventricular (LV) hypertrophy
Design
Cross-sectional
Authors
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Hypothesis-generating for endothelial activation in hypertensive LV hypertrophy; prospective validation needed before clinical consideration.
Cross-Sectional (n=80)
Does sVCAM-1 correlate with left ventricular mass in outpatients with uncomplicated essential hypertension?
Absolute Event Rate: 984.4% vs 759.7%
p-value: p=<0.0001
Plasma sVCAM-1 levels are significantly elevated in and correlated with left ventricular hypertrophy in patients with uncomplicated essential hypertension, suggesting its utility as a biochemical marker for LV mass.
Yoko Kuroda (2001) conducted a cross-sectional in Uncomplicated essential hypertension (n=80). Left ventricular hypertrophy vs. Without left ventricular hypertrophy was evaluated on sVCAM-1 level (p=<0.0001). Left ventricular hypertrophy in patients with uncomplicated essential hypertension was associated with significantly elevated sVCAM-1 levels (984.4 vs 759.7 ng/mL, P<0.0001).
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