Key result
Glutaraldehyde-treated human pericardium shows ~4-fold higher tensile strength than native aortic valve leaflets.
Why the study?
The strength of human pericardium treated with glutaraldehyde for aortic valve reconstruction had not been confirmed compared to aortic valve leaflets with varying calcification.
Does glutaraldehyde-treated human pericardium have comparable tensile strength to native aortic valve leaflets for use in aortic valve reconstruction?
Does glutaraldehyde-treated human pericardium have comparable tensile strength to native aortic valve leaflets for use in aortic valve reconstruction?
Glutaraldehyde-treated human pericardium demonstrates an ultimate tensile strength four times higher than non-calcified aortic leaflets, supporting its biomechanical suitability for aortic valve reconstruction.
Answers are grounded in this paper and cite their sources.
Supports biomechanical suitability of treated pericardium for valve reconstruction; leaves open need for in vivo and clinical validation.
PURPOSE: We have reconstructed aortic valves using autologous pericardium treated with glutaraldehyde since April 2007. However, the strength of the human pericardium has not been confirmed. We compared tensile strength between glutaraldehyde-treated human pericardium and aortic valve leaflets with various degrees of calcification to determine their suitability for use in aortic valve reconstruction. METHODS: We measured the ultimate tensile strength and elasticity of samples of glutaraldehyde-treated pericardia (n = 8), non-calcified (n = 12), calcified (n = 9) and decalcified (n = 21) aortic leaflets collected from 23 patients who underwent aortic valve surgery. Aortic valves were decalcified using a cavitational ultrasonic surgical aspirator. The pericardium was immersed in 0.6% buffered glutaraldehyde for 10 minutes and then rinsed three times for 6 minutes each in normal saline. RESULTS: The ultimate tensile strength of the glutaraldehyde-treated human pericardium, non-calcified, calcified and decalcified leaflets was 10, 2.8, 1.0 and 0.8 MPa, respectively. CONCLUSIONS: The ultimate tensile strength of glutaraldehyde-treated human pericardium was 4 times higher than non-calcified leaflets, indicating its suitability for application to aortic valve reconstruction. Calcified leaflets were slightly stronger than decalcified leaflets. Thus, calcification can be removed without altering the tensile strength of valve materials.
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Yamashita et al. (2012) studied Aortic valve diseases (n=23). Glutaraldehyde treatment vs. Non-calcified aortic valve leaflets was evaluated on Ultimate tensile strength. Glutaraldehyde-treated human pericardium demonstrated an ultimate tensile strength of 10.03 MPa, approximately 4 times higher than non-calcified aortic valve leaflets (2.31 MPa).
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