Key result
High preoperative SBP linked to ~97% higher risk of rectal cancer recurrence or death.
Why the study?
Several studies suggested that hypertension is positively related to cancer incidence and mortality, but the association between perioperative blood pressure and long-term survival in rectal cancer patients was unclear.
Does high perioperative blood pressure affect long-term survival in patients with stages I-III rectal cancer undergoing curative resection?
Population
358 patients with stages I-III rectal cancer undergoing curative resection
Comparison
High perioperative blood pressure (≥120/80 mmHg) vs low perioperative blood pressure (<120/80 mmHg)
Design
Cohort study
Follow-up
3 years
Authors
Loading...
High perioperative systolic BP identifies higher rectal cancer mortality risk; extends observational links but leaves BP control benefit unproven.
Cohort (n=358)
No
Does high perioperative blood pressure affect long-term survival in patients with stages I-III rectal cancer undergoing curative resection?
Hazard Ratio: 1.97 (95% CI 1.08–3.6)
Absolute Event Rate: 67.2% vs 82.1%
p-value: p=0.028
High perioperative systolic blood pressure is an independent risk factor for reduced disease-free and cancer-specific survival in patients undergoing curative resection for rectal cancer.
Yu et al. (2016) conducted a cohort in Stages I-III rectal cancer (n=358). High preoperative systolic blood pressure (≥120 mmHg) vs. Low preoperative systolic blood pressure (<120 mmHg) was evaluated on 3-year disease-free survival (DFS) (HR 1.97, 95% CI 1.08-3.60, p=0.028). High preoperative systolic blood pressure (≥120 mmHg) was independently associated with a lower 3-year disease-free survival rate compared to low systolic blood pressure (adjusted HR 1.97) in patients with rectal cancer.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: