Key result
Thrombus growth rate increases linearly at shear rates beyond 40,000 per second in preclinical models.
Why the study?
Acute occlusive thrombosis events are difficult to capture in patients and animal models may be misleading due to species differences in anti-thrombotic therapeutic cross-reactivity.
Answers are grounded in this paper and cite their sources.
A novel flow-through system using whole porcine blood enables real-time visualization of occlusive thrombosis and may serve as an economic model for testing anti-thrombotic therapies.
Occlusive thrombosis accounts for many heart attacks and strokes. These acute events are difficult to catch in patients and animal test methods may be misleading because anti-thrombotic therapeutics often do not cross-react with different species. This paper presents a new flow-through system that leads to rapid occlusive thrombosis in arterial flow conditions. Whole porcine blood is perfused through a tubular test section. The growing thrombus is visualized in real time from early platelet attachment, through accumulation, to occlusion. The progression of flow rate reduction provides a clear distinguishing parameter between thrombus formation and embolization. Thrombus growth rate is a linear function of very high shear rate beyond 40,000 s(-1). The histology of the thrombus reveals predominantly platelet accumulation and growth as a rough surface with tendrils. This flow-through system may be useful for the economic testing of new anti-thrombosis therapies.
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Ku et al. (2007) studied Occlusive thrombosis. Flow-through system was evaluated on Thrombus growth rate and flow rate reduction. A new flow-through system using whole porcine blood demonstrated that thrombus growth rate is a linear function of very high shear rate beyond 40,000 s(-1).
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