Key result
Diabetic foot ulceration was associated with a significantly higher rate of abnormal autonomic scores compared to controls (62.8% vs 13.5%, P<0.001), which was the best predictor of ulceration.
Why the study?
Is cardiac autonomic dysfunction and peripheral sensory nerve dysfunction associated with a history of foot ulceration in diabetic patients?
Population
531 diabetic patients, comprising 51 with a history of foot ulceration and 480 diabetic control subjects…
Design
Case-control
Authors
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May refine diabetic foot ulcer risk stratification; hypothesis-generating and requires prospective validation before practice change.
Case-Control (n=531)
Is cardiac autonomic dysfunction and peripheral sensory nerve dysfunction associated with a history of foot ulceration in diabetic patients?
Absolute Event Rate: 62.8% vs 13.5%
p-value: p=<0.001
Cardiac autonomic dysfunction is strongly associated with and serves as a significant predictor of foot ulceration in diabetic patients.
McFadden et al. (1991) conducted a case-control in Diabetic foot ulceration (n=531). Diabetic foot ulceration vs. Diabetic control subjects without foot ulceration was evaluated on Abnormal autonomic score (p=<0.001). Diabetic foot ulceration was associated with a significantly higher rate of abnormal autonomic scores compared to controls (62.8% vs 13.5%, P<0.001), which was the best predictor of ulceration.
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