Key result
Diabetics with neuropathic foot ulceration demonstrated significantly greater impairment of cardiovascular autonomic function compared to diabetics with uncomplicated neuropathy.
Why the study?
Is cardiovascular autonomic neuropathy associated with the presence and severity of somatic neuropathy and foot ulceration in diabetic patients?
Population
120 subjects divided into four groups of 30: controls, diabetics without clinical evidence of neuropathy…
Comparison
Five standard, non-invasive tests of… vs Comparisons between the four groups
Design
Cross-sectional
Authors
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Greater autonomic impairment tracks with foot ulceration in diabetes; leaves open whether autonomic testing or intervention alters ulcer risk.
Observational (n=120)
Is cardiovascular autonomic neuropathy associated with the presence and severity of somatic neuropathy and foot ulceration in diabetic patients?
Cardiovascular autonomic neuropathy is progressively more severe in diabetic patients with somatic neuropathy and those with foot ulceration, suggesting a link between autonomic dysfunction and neuropathic ulcers.
Ahmed et al. (1986) conducted an observational in Diabetes with and without neuropathy and foot ulceration (n=120). Diabetes and somatic neuropathy vs. Healthy controls and diabetics without complications was evaluated on Impairment of cardiovascular autonomic function. Diabetics with neuropathic foot ulceration demonstrated significantly greater impairment of cardiovascular autonomic function compared to diabetics with uncomplicated neuropathy.
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