Key result
Radioisotope clearance correlates moderately with plethysmography and distinguishes PAD from normal limbs.
Why the study?
The accuracy and value of plethysmographic blood flow measurement versus the radioisotope test using 131I-labelled serum albumin for assessing peripheral circulation and ischemia were uncertain.
Does the radioisotope test using 131I-labelled serum albumin compare favorably to plethysmographic blood flow measurement for assessing peripheral circulation in normal individuals and patients with peripheral arterial disease?
Population
Normal individuals and patients with peripheral arterial disease
Comparison
Radioisotope test using 131I-labelled serum albumin vs venous occlusion plethysmography
Design
Cross-sectional study
Authors
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Supports radioisotope testing exploration in PAD research; hypothesis-generating and should not yet change practice.
Cross-Sectional
Does the radioisotope test using 131I-labelled serum albumin compare favorably to plethysmographic blood flow measurement for assessing peripheral circulation in normal individuals and patients with peripheral arterial disease?
Effect estimate: r = 0.69
The radioisotope test using 131I-labelled serum albumin appears more valuable than plethysmographic blood flow measurement for differentiating normal individuals from patients with peripheral arterial disease and evaluating ischemia severity.
Cuypers et al. (1981) conducted a cross-sectional in Peripheral arterial disease. Radioisotope test using 131I-labelled serum albumin vs. Venous occlusion plethysmography was evaluated on Relationship between parameter M/2 -- delay of the radioisotope test and plethysmographic blood flow (r = 0.69). The radioisotope test using 131I-labelled serum albumin correlated with plethysmographic blood flow (r = 0.69) and appeared more valuable for differentiating normal individuals from PAD patients.
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