Why the study?
Does venous occlusion plethysmography have a different coefficient of variation compared to 133Xe muscle clearance for measuring calf arterial blood flow in normal subjects?
Does venous occlusion plethysmography have a different coefficient of variation compared to 133Xe muscle clearance for measuring calf arterial blood flow in normal subjects?
Venous occlusion plethysmography has a significantly lower coefficient of variation than 133Xe clearance for measuring calf arterial blood flow during submaximal vasodilatation.
Plethysmography may offer better reproducibility than 133Xe clearance for calf flow; hypothesis-generating, should not yet change practice.
Siggaard-Andersen, J. & Bonde Petersen, F. Venous Occlusion Plethysmography and 133Xe Muscle Clearance Measured Simultaneously on the Calf in Normal Subjects. Scand. J. din. Lab. Invest. 19, 106-112, 1967. The arterial blood flow/volume in the calf was determined simultaneously by venous occlusion plethysmography, using the DOHN plethysmograph, and by the 133Xe clearance technique in the anterior tibial muscle.Ten young experimental subjects had each lower extremity tested five times, during the period of hyperaemia following ischaemia, ischaemia+light exercise (0.18 kgm/min.), and exercise alone, giving a total of 100 determinations for each of the three experimental conditions.The coefficient of variation for the highest measured flow/volume under these conditions of submaximal vasodilatation was 13 per cent for plethysmography and 21 per cent for 133Xe clearance. This difference is significant (p<0.001).
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Siggaard-Andersen et al. (1967) studied this question.
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