Key result
Microdialysis ethanol technique strongly correlates with 133Xe clearance for measuring skeletal muscle blood flow changes.
Why the study?
The validity of the microdialysis ethanol technique for measuring local skeletal muscle blood flow during intermittent isometric contractions was evaluated against 133Xe clearance.
Does the microdialysis ethanol technique provide a valid measure of changes in local skeletal muscle blood flow compared to 133Xe clearance?
Population
6 subjects performing intermittent isometric thigh contractions at 0-60% maximal voluntary isometric contraction force
Comparison
Microdialysis ethanol technique vs 133Xe clearance technique for measuring muscle blood flow
Design
Observational study
Authors
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May support microdialysis for exercise physiology studies; leaves open clinical validation in patients.
Observational (n=6)
Does the microdialysis ethanol technique provide a valid measure of changes in local skeletal muscle blood flow compared to 133Xe clearance?
Effect estimate: r = -0.92
The microdialysis ethanol technique provides a valid measure of changes in local skeletal muscle blood flow, correlating highly with the established 133Xe clearance method.
Hickner et al. (1994) reported an observational. Microdialysis ethanol technique vs. 133Xe clearance was evaluated on Correlation between the ethanol outflow/inflow ratio and 133Xe clearance (r = -0.92). The microdialysis ethanol technique provided a valid measure of changes in local skeletal muscle blood flow, strongly correlating with 133Xe clearance (median r = -0.92).
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