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January 1, 1984Journal of Applied Physiology

Blood flow in exercising muscles by xenon clearance and by microsphere trapping

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Why the study?

Does the 133Xe clearance method accurately measure muscle blood flow compared to direct venous outflow and microsphere trapping in dogs?

Population

11 isolated perfused dog gastrocnemius muscles and 2 intact dogs

Comparison

133Xe clearance method for muscle blood flow… vs Direct venous outflow and microsphere trapping…

Design

Preclinical

Authors

PCP. CerretelliInstitute of Molecular Bioimaging and PhysiologyCMC. MarconiUniversity of GenevaDPD. R. PendergastUniversity at Buffalo, State University of New York

Discussion

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Implication

133Xe clearance underestimates muscle blood flow in dogs; leaves open its validity in humans and should not yet change practice.

Structured PICO

Does the 133Xe clearance method accurately measure muscle blood flow compared to direct venous outflow and microsphere trapping in dogs?

P
Population
11 isolated perfused dog gastrocnemius muscles and 2 intact dogs
I
Intervention
133Xe clearance method (QXe) for muscle blood flow measurement
C
Comparator
Direct venous outflow (Qv) and microsphere trapping flow (Q mu)
O
Outcome
Accuracy of muscle blood flow measurementsurrogate

The 133Xe clearance method significantly underestimates muscle blood flow in dogs compared to direct venous outflow and microsphere trapping.

Cite This Study

Cerretelli et al. (1984) studied this question.

synapsesocial.com/papers/6a0ee0d906ecbe833447ea06https://doi.org/10.1152/jappl.1984.56.1.24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Relation Between Blood Flow in an Isolated Muscle Measured with the Xe133 Clearance and a Direct Recording Technique1967 · 79 citations
  2. 2Validity of the Xenon 133 Method for Measurement of Muscle Blood Flow Evaluated by Simultaneous Venous Occlusion Plethysmography1965 · 74 citations
  3. 3Venous Occlusion Plethysmography and133Xe Muscle Clearance Measured Simultaneously on the Calf in Normal Subjects1967 · 29 citations
  4. 4Estimation of Relative Changes in Resting Muscle Blood Flow by133Xe Washout: The Effect of Oxygen1973 · 18 citations
  5. 5Muscle Blood Flow during Intermittent Exercise: Comparison of the Microdialysis Ethanol Technique and 133Xe Clearance1994 · 81 citations