Key result
Carotid-related ischemic stroke alters LDL and HDL function post-event, showing partial reversal at 1 year.
Why the study?
Lipoproteins play a crucial role in atherosclerosis development after ischemic stroke, but alterations in their composition and function over time were not well characterized.
Population
64 ischemic stroke patients with carotid atherosclerosis and 27 healthy controls
Comparison
Patients with carotid atherosclerosis vs healthy controls
Design
Observational cohort study
Follow-up
1 year
Authors
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Post-stroke lipoprotein alterations may elevate residual risk; leaves open whether functional profiling should inform secondary prevention in carotid atherosclerosis.
Observational (n=91)
Lipoprotein dysfunction and pro-inflammatory alterations observed acutely after ischemic stroke with carotid atherosclerosis are transient and partially reverse by 1 year.
Puig et al. (2024) conducted an observational in Ischemic stroke with carotid atherosclerosis (n=91). Ischemic stroke with carotid atherosclerosis vs. Healthy controls was evaluated on Qualitative properties of lipoproteins (LDL and HDL composition and function). Ischemic stroke patients with carotid atherosclerosis exhibited alterations in LDL and HDL composition and function at 7 days post-stroke, which were partially reversed after 1 year.
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