Low plasma adiponectin is associated with coronary artery disease but not with hypertension in high‐risk nondiabetic patients
Key result
Higher adiponectin levels are linked to lower CAD atherosclerotic burden in nondiabetic patients.
- beta = -0.12
- P=0.029
- n=400
Why the study?
The association of plasma adiponectin levels with coronary artery disease, hypertension, and insulin resistance in nondiabetic patients was unclear.
Are plasma adiponectin levels associated with coronary artery disease severity, hypertension, and insulin resistance in high-risk nondiabetic patients?
Population
400 nondiabetic Caucasian patients undergoing coronary angiography
Comparison
Plasma adiponectin levels in patients with and without CAD, HT, and IR
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
Low adiponectin marks greater CAD burden independent of hypertension; leaves open its value as a biomarker pending prospective validation.
Study Design
Type
Cross-Sectional (n=400)
Structured PICO
Are plasma adiponectin levels associated with coronary artery disease severity, hypertension, and insulin resistance in high-risk nondiabetic patients?
P
Population
400 nondiabetic Caucasian patients undergoing coronary angiography evaluated for associations between plasma adiponectin and cardiovascular conditions.
E
Exposure
Plasma adiponectin levels
O
Outcome
Coronary artery disease atherosclerotic burden (angiography-based modified Duke Index score), arterial hypertension, and insulin resistance (HOMA index)surrogate
Main Result
Effect estimate: beta = -0.12
p-value: p=0.029
Low plasma adiponectin is associated with increased coronary artery disease severity and insulin resistance, but not hypertension, in high-risk nondiabetic patients.
Cite This Study
Cesari et al. (2006) conducted a cross-sectional in Coronary artery disease, hypertension, and insulin resistance (n=400). Plasma adiponectin levels was evaluated on Coronary artery disease atherosclerotic burden (angiography-based modified Duke Index score) (beta = -0.12, p=0.029). Plasma adiponectin levels were inversely related to the coronary artery disease atherosclerotic burden (beta = -0.12, P = 0.029) in nondiabetic Caucasian patients.