A study of the association about serum TGF-β1 and IL-6 in wet age-related macular degeneration

Objective To observed the change of serum inflammatory-associated cytokines concentrations in the patients with wet age-related macular degeneration.Methods Retrospective analysis was made to the serum inflammatory cytokines of the 55 patients with wet AMD.The serum of 33 patients with senile cataract was selected as the control group.Serous concentrations of TGF-β1,IL-6,and MCP-1 were examined by enzyme-linked immunosorbent assay (ELISA).Results The levels of TGF-β 1,IL-6 in wet AMD group were significantly higher than that in control group (Z =-3.228,P =0.001; Z =-2.034,P =0.042).The level of MCP-1 was not significantly different between the two groups (Z =-1.832,P =0.067).Conclusions The serum inflammatory-associated cytokines TGF-β1,IL-6 may be the biomarker to monitor the progression of wet AMD.