Biochemical synthesis study demonstrates a two-step route to 9,11-secosteroids from cortisol, highlighting a sustainable biocatalytic pathway avoiding toxic oxidants.
A method for the synthesis of 9,11-secosteroids starting from the natural corticosteroid cortisol is described. There are two key steps in this approach, combining chemistry and synthetic biology. Stereo- and regioselective hydroxylation at C9 (steroid numbering) is carried out using whole-cell biocatalysis, followed by the chemical cleavage of the C-C bond of the vicinal diol. The two-step method features mild reaction conditions and completely excludes the use of toxic oxidants.
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Kõllo et al. (2021) studied this question.
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