Key result
Translocation of the S4 voltage-sensing helices of cardiac L-type calcium channels initiates excitation-contraction coupling in response to sarcolemma depolarization.
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Design
Editorial
Discusses the mechanisms of excitation-contraction coupling in the heart, focusing on L-type Ca2+ channels.
In the heart, translocation of the S4 voltage-sensing helices of cardiac L-type Ca2+ channels (or 1,4-dihydropyridine receptors [DHPRs]) in response to depolarization of the sarcolemma is the initial event in excitation–contraction (EC) coupling. The movement of the voltage sensors is in turn
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Beam et al. (2010) studied this question. Translocation of the S4 voltage-sensing helices of cardiac L-type calcium channels initiates excitation-contraction coupling in response to sarcolemma depolarization.
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