Key result
Nifedipine and propranolol fail to inhibit collagen-induced platelet aggregation alone or combined.
Why the study?
The effects of nifedipine and propranolol, alone and in combination, on collagen-induced platelet aggregation in healthy volunteers were unclear.
Do nifedipine and propranolol, alone or in combination, inhibit collagen-induced platelet aggregation in healthy volunteers?
Do nifedipine and propranolol, alone or in combination, inhibit collagen-induced platelet aggregation in healthy volunteers?
Nifedipine and propranolol do not appear to significantly inhibit collagen-induced platelet aggregation in healthy volunteers.
Does not support antiplatelet effects in clinical use; leaves open their impact on platelet function in cardiovascular disease.
The effects of nifedipine and propranolol, alone and in combination, on collagen-induced platelet aggregation were studied in healthy volunteers using whole blood impedance aggregometry. No significant inhibition of platelet aggregation was found after the in vitro addition of propranolol, nifedipine or nifedipine vehicle or after nifedipine ex vivo. No interaction was found between in vitro propranolol and nifedipine, either in vitro or ex vivo.
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Donaldson et al. (1991) studied Healthy volunteers. Nifedipine and propranolol vs. Vehicle or alone was evaluated on Collagen-induced platelet aggregation. Nifedipine and propranolol, alone or in combination, demonstrated no significant inhibition of collagen-induced platelet aggregation in healthy volunteers.
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