Key result
Anti-P-selectin antibody lowers inflammatory cytokines and respiratory index during CPB in preclinical model.
Why the study?
The role of P-selectin in the inflammatory response induced by cardiopulmonary bypass has never been clarified.
Does an anti-P-selectin monoclonal antibody reduce inflammatory cytokines and lung injury in a rat cardiopulmonary bypass model?
Does an anti-P-selectin monoclonal antibody reduce inflammatory cytokines and lung injury in a rat cardiopulmonary bypass model?
In a rat model, an anti-P-selectin monoclonal antibody attenuated the release of inflammatory cytokines and lung injury induced by cardiopulmonary bypass.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications for cardiopulmonary bypass; leaves open translation of P-selectin inhibition to human trials.
Hayashi et al. (2000) studied Cardiopulmonary bypass induced inflammatory response and lung injury (n=20). Anti-rat specific P-selectin monoclonal antibody (ARP2-4) vs. Saline alone was evaluated on Inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL-8) and respiratory index (RI). In a rat model of cardiopulmonary bypass, an anti-rat specific P-selectin monoclonal antibody significantly lowered plasma levels of IL-6, IL-8, and respiratory index compared to saline.
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