Key result
DHE-CMR outperforms ECG and echocardiography for diagnosing biopsy-proven cardiac amyloidosis.
Why the study?
In patients with nonischemic cardiomyopathy and suspected cardiac amyloidosis, multiple noninvasive parameters have been used but their diagnostic accuracy compared to endomyocardial biopsy is unclear.
Does delayed hyper-enhancement cardiac magnetic resonance imaging improve diagnostic accuracy compared to other noninvasive parameters in patients with suspected cardiac amyloidosis?
Observational
Does delayed hyper-enhancement cardiac magnetic resonance imaging improve diagnostic accuracy compared to other noninvasive parameters in patients with suspected cardiac amyloidosis?
Delayed hyper-enhancement cardiac magnetic resonance imaging reveals a characteristic diffuse enhancement pattern that is more accurate than ECG and TTE for diagnosing cardiac amyloidosis.
Answers are grounded in this paper and cite their sources.
May support CMR for suspected cardiac amyloidosis diagnosis; leaves open prospective validation against biopsy.
In patients with nonischemic cardiomyopathy and suspected cardiac amyloidosis (CA), endomyocardial biopsy (EMB) provides a definitive diagnosis. A multitude of noninvasive parameters, including electrocardiography (ECG) and transthoracic echocardiography (TTE) have been utilized as potential markers of CA. Recently, it has been demonstrated that, in patients with CA, delayed hyper-enhancement cardiac magnetic resonance (DHE-CMR) reveals a characteristic diffuse enhancement of the entire subendocardium (arrows) with extension into the neighboring myocardium (Figure 1 ).
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Austin et al. (2009) conducted an observational in Cardiac amyloidosis. Delayed hyper-enhancement cardiac magnetic resonance imaging (DHE-CMR) vs. Other noninvasive parameters (ECG, TTE) was evaluated on Diagnosis of cardiac amyloidosis. Delayed hyper-enhancement cardiac magnetic resonance imaging is more accurate than other noninvasive parameters in diagnosing endomyocardial biopsy-positive cardiac amyloidosis.
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