The preliminary objective of the work is to develop the meter dose formulation of xylometazoline hydrochloride for enhanced effectiveness for nasal decongestion.The 3 2 factorial design was utilized for development of the formulation, where sodium cholate (X1) and Polyethyleneglycol 400 concentration (X2) were independent factors.The optimized formulation composition consisted of 0.1g sodium cholate and 1.5ml Polyethyleneglycol 400 independent varibales.The formulation was evaluated for solution parameters like assay, pH, viscosity, % diffusion, sterility, content uniformity, pump delivery, spray pattern, and weight loss.The percentage diffusion and viscosity was observed 81.00±2.00%and 24.33±0.57centipoise respectively.The meter dose nasal formulation provides alternative option for treatment of nasal decongestion which showed comparable results to marketed formulation.
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Falgun Bhuva (2018) studied this question.
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