Key result
Novel technologies and cellular models promise new insights into early youth atherosclerosis pathogenesis.
Why the study?
Understanding the pathogenesis of atherosclerosis, especially early lesions in youth, is important and timely given new hypotheses and technological advances.
Highlights the potential of cellular and animal models combined with new technologies to advance the understanding of early atherosclerosis in youth.
Does not yet support practice changes in youth atherosclerosis prevention; leaves open whether new models will clarify early lesion mechanisms.
The current interest in vascular lesions formed during childhood and adolescence is both pertinent and timely, as atherosclerosis research has never been more exciting that at the present. A number of attractive hypotheses about the pathogenesis of atherosclerosis have been proposed which provide different perspectives for understanding the disease process. A host of animal and cell models of early lesions are now available for study and new technological advances, such as recombinant DNA techniques and sensitive imaging procedures, will allow these models to be studied in greater depth. Consequently, the next decade should bring new insight on the pathogenesis of atherosclerosis, especially the early lesions of youth.
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Fowler et al. (1991) conducted a review in Atherosclerosis in the young. New technological advances and cellular models are expected to provide new insights into the pathogenesis of early atherosclerotic lesions in youth over the next decade.
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