Key result
A combined electrophysiological and optical approach revealed that the eag voltage sensor undergoes previously undetected conformational changes that account for the time course of activation.
Population
Voltage-dependent ether-à-go-go (eag) K+ channels
Comparison
Combined electrophysiological and optical… vs Absence of extracellular Mg2+
Design
Preclinical
Authors
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Optical detection uncovers hidden eag voltage sensor transitions; extends gating current models of divalent modulation.
This study reveals previously undetected conformational changes in the eag K+ channel voltage sensor that explain the time course of its activation and modulation by Mg2+.
Bannister et al. (2005) studied this question. Extracellular Mg2+ vs. Absence of extracellular Mg2+ was evaluated on Conformational changes of the voltage sensor. A combined electrophysiological and optical approach revealed that the eag voltage sensor undergoes previously undetected conformational changes that account for the time course of activation.
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