Key result
Higher hemoglobin levels are linked to lower HbA1c independently of fasting glucose in non-diabetic adults.
Why the study?
The relationship between hemoglobin levels, sex, and HbA1c levels in Japanese individuals without diabetes or anemia was unclear.
Do hemoglobin levels and sex affect HbA1c levels in Japanese men and women without diabetes or anemia?
Cross-Sectional (n=32,605)
No
Do hemoglobin levels and sex affect HbA1c levels in Japanese men and women without diabetes or anemia?
p-value: p=<0.001
Hemoglobin levels inversely affect HbA1c levels independently of other factors, suggesting caution is needed when using HbA1c to screen for glucose intolerance.
HbA1c may vary with hemoglobin independent of glycemia; hypothesis-generating for adjusted thresholds in non-diabetic screening.
HbA1c levels decreased with increasing Hb levels, independent of age, sex, BMI, FPG, and smoking and alcohol habits in Japanese men and women without diabetes or anemia. There was an interaction between sex and hemoglobin in the effects on HbA1c. The interpretation of HbA1c values should be cautious in the screening of glucose intolerance.
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Nakagami et al. (2017) conducted a cross-sectional in Healthy individuals without diabetes or anemia (n=32,605). Hemoglobin levels vs. Lower hemoglobin levels was evaluated on HbA1c levels (p=<0.001). HbA1c levels decreased significantly with increasing hemoglobin levels, independent of fasting plasma glucose and other covariates, in Japanese men and women without diabetes or anemia (P < 0.001).
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