Why the study?
Are CHA2DS2-VASc scores associated with left atrial enlargement and serum D-dimer levels in anticoagulation-naïve patients with acute ischemic stroke due to NVAF?
Population
98 anticoagulation-naïve patients presenting with acute ischemic stroke due to non-valvular atrial…
Design
Cross-sectional
Key result
Higher CHA2DS2-VASc scores were significantly correlated with increased left atrial volume index (r=0.325, P=0.002) and elevated serum D-dimer levels (r=0.309, P=0.006) in NVAF patients with stroke.
Authors
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May inform integrated risk models in NVAF stroke; leaves open whether LA volume or D-dimer refines CHA2DS2-VASc utility.
Cross-Sectional (n=98)
Are CHA2DS2-VASc scores associated with left atrial enlargement and serum D-dimer levels in anticoagulation-naïve patients with acute ischemic stroke due to NVAF?
Effect estimate: r=0.325 (LAVI); r=0.309 (D-dimer)
p-value: P=0.002 (LAVI); P=0.006 (D-dimer)
Higher CHA2DS2-VASc scores correlate with left atrial enlargement and elevated D-dimer levels in anticoagulation-naïve patients with NVAF and acute ischemic stroke, suggesting these factors contribute to thrombogenesis.
Kim et al. (2016) conducted a cross-sectional in Acute ischemic stroke due to non-valvular atrial fibrillation (NVAF) (n=98). CHA2DS2-VASc score was evaluated on Correlation of CHA2DS2-VASc scores with left atrial volume index (LAVI) and serum D-dimer levels (r=0.325 (LAVI); r=0.309 (D-dimer), p=P=0.002 (LAVI); P=0.006 (D-dimer)). Higher CHA2DS2-VASc scores were significantly correlated with increased left atrial volume index (r=0.325, P=0.002) and elevated serum D-dimer levels (r=0.309, P=0.006) in NVAF patients with stroke.
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