Key result
Sustained hypertension links to LVH and PAD, affecting ~52% of older Tanzanian adults.
Why the study?
Few data from sub-Saharan Africa exist on the effects of hypertension on end organ damage in older adults.
Is sustained hypertension associated with end organ damage in older adults in rural Tanzania?
Cohort (n=246)
Yes
Is sustained hypertension associated with end organ damage in older adults in rural Tanzania?
In an elderly cohort in rural Tanzania, sustained hypertension is highly prevalent and significantly associated with end-organ damage such as left ventricular hypertrophy and peripheral arterial disease.
Few data from sub-Saharan Africa exist on the effects of hypertension on the organs of the human body. We aimed to establish the prevalence of hypertensive end organ damage (EOD) in an elderly cohort of Tanzanians. The population aged 70 years and over of 2 villages in northern Tanzania (n = 246), had blood pressure (BP) data available from 2010 and 2013, and underwent in-depth follow-up for markers of hypertensive EOD in 2016. Assessment included ankle-brachial pressure index, lying-standing BP, electrocardiogram, and mid-stream urine dip. Sustained hypertension (those with hypertension at all 3 assessments) was found in 129 (52.4% subjects). Of the entire cohort, 13.9% had left ventricular hypertrophy and 26.4% had peripheral arterial disease, both of which were associated with sustained hypertension, although orthostatic hypotension, stroke, proteinuria, and arterial stiffening were not. Further investigation, particularly in younger age groups, is merited if hypertension-associated morbidity is to be controlled.
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Putnam et al. (2018) conducted a cohort in Hypertension (n=246). Sustained hypertension vs. No sustained hypertension was evaluated on Hypertensive end organ damage (including left ventricular hypertrophy and peripheral arterial disease). Sustained hypertension was present in 52.4% of older Tanzanian adults and was associated with left ventricular hypertrophy and peripheral arterial disease, but not stroke or arterial stiffening.
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