Key result
Among 78 patients with cutaneous Ewing sarcoma, only 10 developed metastatic disease and 91% remained alive despite wide variations in treatment regimens.
Cutaneous Ewing sarcoma is a less aggressive variant with high survival rates, suggesting that local control with surgery and/or radiation and abbreviated chemotherapy may be an appropriate treatment option.
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Supports favorable prognosis in cutaneous Ewing sarcoma; hypothesis-generating for de-escalated regimens.
Cutaneous Ewing sarcoma is a rare variant that has been poorly characterized and has no standard therapy. We report 2 patients with cutaneous Ewing sarcoma and review 76 other cases reported in the literature for demographics, presentation, treatment, and outcome. Only 2 patients presented with metastatic disease, and only 8 patients developed metastatic disease. Ninety-one percent of all patients are alive despite wide variations in treatment regimens. On the basis of this summary, treatment consisting of local control with surgery and/or radiation and abbreviated chemotherapy is proposed as a treatment option for this less aggressive Ewing sarcoma.
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Collier et al. (2011) conducted a review in Cutaneous Ewing sarcoma (n=78). Various treatment regimens was evaluated on Survival and metastatic disease. Among 78 patients with cutaneous Ewing sarcoma, only 10 developed metastatic disease and 91% remained alive despite wide variations in treatment regimens.
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