Key result
Propranolol linked to severe, reversible dose-dependent depression in small case series.
Why the study?
Depressive episodes associated with propranolol use, especially dose-dependent and reversible upon discontinuation, require increased physician awareness.
Does propranolol cause depressive episodes in patients treated for medical illnesses?
Case Report (n=3)
Does propranolol cause depressive episodes in patients treated for medical illnesses?
Propranolol administration can induce severe, dose-dependent depressive episodes that resolve upon drug discontinuation.
No takes yet. Share an insight, caveat, or question.
Propranolol may induce severe reversible depression; case reports leave open causality and do not support practice change.
Petrie et al. (1982) conducted a case report in Depression (n=3). Propranolol was evaluated on Depressive episodes. Propranolol administration was associated with severe, dose-dependent depressive episodes in 3 patients, which promptly remitted upon drug discontinuation.
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