Why the study?
Does propranolol reduce blood pressure in patients with mild to moderate hypertension?
Does propranolol reduce blood pressure in patients with mild to moderate hypertension?
Propranolol demonstrates a hypotensive effect, adequately controlling blood pressure in 30-40% of patients with mild to moderate hypertension.
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Should not change practice; leaves open propranolol's role versus contemporary agents in randomized data.
Coronary heart disease together with sudden cardiac death is now the main cause of death in patients being treated for hypertension at the Wellcome Medical Research Institute, probably because of a reduction in deaths from heart failure and stroke. A hypotensive agent with antiarrhythmic properties might, therefore, be valuable. This work confirms the hypotensive action of the antiarrhythmic agent propranolol in hypertensive patients. In subiects with mild to moderate hypertension, propranolol controlled the hypertension adequately in 30 to 40 per cent. The dose was higher than that necessary for antiarrhythmic effects. The hypotensive effect of propranolol was fully estahlished after one day; no cumulation but rather mild tolerance developed.
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Hendrika J. Waal (1966) studied this question.
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