What question did this study set out to answer?

This research aims to compare the efficacy of propranolol in treating hypertension against conventional drugs.

January 4, 1969BMJOpen Access

Treatment of Hypertension with Propranolol

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Why the study?

Does propranolol improve blood pressure control compared to conventional drugs in hypertensive patients?

Key Points

This research aims to compare the efficacy of propranolol in treating hypertension against conventional drugs.
109 hypertensive patients treated with propranolol, with gradual dosage increase.
Follow-up conducted on 17 patients for comparison with other hypertension drugs.
Blood pressure measurements taken in supine and standing positions.
Achieved supine or standing blood pressure of 100 mm. Hg or less in 92 patients.
More patients experienced diastolic pressures of 100 mm. Hg or less after propranolol compared to guanethidine, bethanidine, or methyldopa.
Maximum hypotensive effect reached after six to eight weeks.

Structured PICO

Does propranolol improve blood pressure control compared to conventional drugs in hypertensive patients?

Population

109 hypertensive patients, 80 of whom had previously been treated with other potent drugs.

Intervention

Propranolol (dosage increased gradually)

Comparator

Previous treatment with guanethidine, bethanidine, or methyldopa (in a subset of 17 patients)

Outcome

Achievement of supine or standing diastolic blood pressure of 100 mm Hg or lesssurrogate

Propranolol is an effective and well-tolerated treatment for hypertension, achieving good blood pressure control without the postural hypotension associated with older agents.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not change practice; leaves open propranolol's role versus contemporary agents in diverse populations.

Cite This Study

Prichard et al. (1969) studied this question.

synapsesocial.com/papers/6a711d1126a7f98052dd88fa https://doi.org/10.1136/bmj.1.5635.7

Topics

Hypertension management

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Treatment of Hypertension with Propranolol

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Treatment of Hypertension with Propranolol

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider