What does this research mean for the field?

Propranolol administered at doses up to 400 mg daily, alone or combined with methyldopa, significantly reduces systolic and diastolic blood pressure in patients with hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the blood pressure-lowering effects of propranolol given alone or in combination with methyldopa in hypertensive patients with and without angina pectoris.

July 1, 1968Postgraduate Medical JournalOpen Access

Propranolol in hypertension

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Key result

Propranolol up to 400 mg daily linked to lower BP in hypertensive patients.

Why the study?

Does propranolol reduce systolic and diastolic blood pressure in hypertensive patients?

Population

24 hypertensive patients, 11 of whom had angina pectoris

Design

Cohort

Authors

STShakul TewariBirla Institute of Technology and Science - Hyderabad Campus RGR. H. E. GrantUniversity of Manchester

Discussion

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Implication

May support propranolol in hypertension management; leaves open comparative efficacy versus modern agents in randomized trials.

Key Points

To assess the blood pressure-lowering effects of propranolol given alone or in combination with methyldopa in hypertensive patients with and without angina pectoris.
Treated 24 hypertensive patients (N=24), 11 of whom also had angina pectoris.
Administered propranolol in doses up to 400 mg daily, with the 13 patients without angina receiving concurrent methyldopa at 2 g daily.
Both the propranolol monotherapy group and the propranolol-plus-methyldopa combination group showed significant reductions in systolic blood pressure (effect size and p-value not reported).
Both treatment groups achieved significant reductions in diastolic blood pressure (effect size and p-value not reported).

Structured PICO

Does propranolol reduce systolic and diastolic blood pressure in hypertensive patients?

Population

24 hypertensive patients, 11 of whom had angina pectoris

Intervention

Propranolol in doses up to 400 mg daily (13 patients without angina also received methyldopa 2 g daily)

Outcome

Reduction of systolic and diastolic blood pressuresurrogate

Propranolol, alone or in combination with methyldopa, significantly reduces systolic and diastolic blood pressure in hypertensive patients.

Cite This Study

Tewari et al. (1968) studied this question. Propranolol in doses up to 400 mg daily, alone or combined with methyldopa, significantly reduced systolic and diastolic blood pressure in hypertensive patients.

synapsesocial.com/papers/6aa6a0c889092379003a73e5 https://doi.org/10.1136/pgmj.44.513.509

Topics

Hypertension management

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Propranolol in hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Propranolol in hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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