Key result
Specific HIF-1α gene variants are linked to increased risk of hypertensive LVH.
Why the study?
The effect of HIF-1α gene polymorphisms on left ventricular hypertrophy in hypertensive patients was investigated to clarify their association.
Are HIF-1α gene polymorphisms associated with left ventricular hypertrophy in hypertensive patients?
Observational (n=583)
Are HIF-1α gene polymorphisms associated with left ventricular hypertrophy in hypertensive patients?
p-value: p=<0.05
HIF-1α gene polymorphisms (rs11549465 and rs11549467) are associated with an increased risk of left ventricular hypertrophy in Chinese Han hypertensive patients.
Hypothesis-generating for HIF-1α genotyping in hypertensive LVH; prospective validation required before any clinical adoption.
OBJECTIVE: To investigate the effect of gene polymorphisms in hypoxia-inducible factor 1α (HIF-1α) in left ventricular hypertrophy of hypertensive patients. PATIENTS AND METHODS: A total of 583 hypertensive patients were divided into two groups, with left ventricular hypertrophy (LVH (+), 198 cases) and without left ventricular hypertrophy (LVH (-), 385 cases). Polymerase Chain Reaction restriction fragment length polymorphism was used to detect the single nucleotide gene polymorphisms rs11549465, rs11549467 and rs1957757 in HIF-1α. RESULTS: The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05). The T allele of rs11549465 loci and the G allele of rs11549467 loci increased the risk of LVH, related to the increased plasma expression of HIF-1α (p<0.05). CONCLUSIONS: Gene polymorphism of HIF-1α were related to primary hypertensive left ventricular hypertrophy, and the expression of rs11549467 correlated with the increasing concentration of plasma HIF-1α.
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Zl et al. (2019) conducted an observational in Hypertension with or without left ventricular hypertrophy (n=583). HIF-1α gene polymorphisms (rs11549465, rs11549467, rs1957757) vs. Other alleles was evaluated on Presence of left ventricular hypertrophy (p=<0.05). The T allele of rs11549465 and the G allele of rs11549467 in the HIF-1α gene were associated with an increased risk of primary hypertensive left ventricular hypertrophy (p<0.05).
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