Key result
Gap junctions in Novikoff hepatoma cells are sensitive to physiological internal calcium (≤500 nM), whereas low internal pH without increased calcium does not decrease conductance.
Population
Novikoff hepatoma cell pairs
Comparison
Varying intracellular calcium concentrations and… vs Different pCai and pHi values
Design
Preclinical
Authors
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May guide tumor coupling studies; leaves open whether calcium or pH effects predominate in cardiac gap junctions.
p-value: p=0.0178
Gap junctions in Novikoff hepatoma cells are sensitive to physiological intracellular calcium levels, and low intracellular pH does not independently decrease conductance or increase calcium sensitivity.
Lazrak et al. (1993) studied Novikoff hepatoma cells (in vitro). Internal calcium concentration and pH manipulation was evaluated on Gap junction conductance (Gj) decay (p=0.0178). Gap junctions in Novikoff hepatoma cells are sensitive to physiological internal calcium (≤500 nM), whereas low internal pH without increased calcium does not decrease conductance.
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