Key result
Streptokinase cuts remaining aortic clot weight ~46% in feline arterial thrombosis.
Why the study?
The dosage of streptokinase that produces systemic fibrinolysis and its relative safety in cats were not established.
Does streptokinase reduce clot burden in cats with experimentally induced aortic thrombosis?
Does streptokinase reduce clot burden in cats with experimentally induced aortic thrombosis?
Streptokinase infusion reduced the mean weight of remaining clot in a feline model of experimentally induced aortic thrombosis, though without predictable improvement in angiograms or thermal indices.
Provides preliminary evidence in an experimental feline model; leaves open translation to spontaneous aortic thrombosis in cats.
An investigation was initiated to determine the dosage of streptokinase (given IV) that would consistently produce systemic fibrinolysis, as determined by laboratory evaluation, and to determine the relative safety of this drug in the cat. Results indicated that a loading dose of 90,000 IU of streptokinase (given by continuous infusion over 20 to 30 minutes) and a maintenance dosage (IV) of 45,000 IU of streptokinase/hr predictably produced systemic fibrinolysis in the cat. There were no detectable adverse affects seen on physical examination, necropsy, or histopathologic examination. Using the foregoing dosage regimen, investigation was begun to evaluate the use of streptokinase for treatment of feline thromboembolism. Aortic thrombosis was created experimentally in 15 cats. There was no clearly predictable improvement in nonspecific venous angiograms or thermal circulatory indices for the cats given streptokinase, compared with the values for the control cats. After a total of 180 minutes of treatment, the mean weight of remaining clot removed at necropsy from the aortic trifurcation was 7.3 mg in the streptokinase-treated cats, compared with 13.4 mg in the control cats.
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Killingsworth et al. (1986) studied Aortic thrombosis (n=15). Streptokinase vs. Control was evaluated on Mean weight of remaining clot removed at necropsy from the aortic trifurcation. Streptokinase treatment for 180 minutes in cats with experimentally induced aortic thrombosis resulted in a mean remaining clot weight of 7.3 mg compared with 13.4 mg in controls.
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