Key result
Simultaneous Doppler measurement of TS(E-E') accurately detects pseudonormal filling with an AUC of ~0.91.
Why the study?
The feasibility and clinical usefulness of simultaneous measurement of TS(E-E') for evaluating left ventricular diastolic function were not established.
Does simultaneous measurement of TS(E-E') accurately detect pseudonormal filling in patients evaluated for diastolic function?
Cross-Sectional (n=105)
Does simultaneous measurement of TS(E-E') accurately detect pseudonormal filling in patients evaluated for diastolic function?
Simultaneous measurement of TS(E-E') using pulsed-wave Doppler provides a highly accurate and feasible method for detecting pseudonormal diastolic function.
Answers are grounded in this paper and cite their sources.
May support TS(E-E') for distinguishing diastolic patterns; leaves open its incremental value pending validation studies.
BACKGROUND: In this study, we evaluated the feasibility and clinical usefulness of TS(E-E(') ), the time interval between the onsets of early diastolic mitral inflow velocity (E) and mitral annular velocity (E'), obtained by simultaneously tracing E and E', in terms of evaluating diastolic function. METHODS: By the diastolic functional status, 105 patients were allocated to abnormal relaxation, pseudonormal filling (PN), or normal diastolic function groups (n = 30, 43, and 32, respectively). The TS(E-E(') ) was measured in the same cardiac cycle by the pulsed-wave Doppler (PWD) tracing of mitral inflow near the septal annulus with appropriate filter and gain settings. RESULTS: TS(E-E(') ) was prolonged in the PN group versus the normal group (34.1 +/- 12.2 msec versus 12.1 +/- 8.5 msec, p< or =0.001). The area under the receiver operating characteristic curve of TS(E-E(') ) for the detection of PN was 0.91 (95% confidence interval [CI]; 0.85 approximately 0.97, p<0.001), and 24.0 msec was determined to be the optimal cut-off value (specificity 83.7%, sensitivity 90.3%). CONCLUSION: Simultaneous measurement of TS(E-E(') ) is feasible and clinically applicable for the grading of diastolic dysfunction (DD).
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Choi et al. (2008) conducted a cross-sectional in Diastolic dysfunction (n=105). Simultaneous Doppler tracing of TS(E-E') vs. Normal diastolic function was evaluated on Detection of pseudonormal filling (PN) (AUC 0.91, 95% CI 0.85-0.97, p=<0.001). Simultaneous Doppler tracing of TS(E-E') detected pseudonormal filling with an AUC of 0.91 (95% CI 0.85-0.97, p<0.001) and an optimal cut-off of 24.0 msec.
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