Key result
Elevated serum RBP4 is linked to acute coronary syndrome and greater coronary disease severity.
Why the study?
Previous human studies investigating the role of serum retinol binding protein 4 (RBP4) in cardiovascular disease have shown conflicting results regarding its association with coronary artery disease.
Do elevated serum RBP4 levels correlate with the presence and severity of coronary artery disease in patients presenting with acute coronary syndrome?
Case-Control (n=98)
No
Do elevated serum RBP4 levels correlate with the presence and severity of coronary artery disease in patients presenting with acute coronary syndrome?
Absolute Event Rate: 68.4% vs 49.46%
p-value: p=0.014
Serum RBP4 levels are elevated in patients with acute coronary syndrome and correlate with the angiographic severity of coronary artery disease.
RBP4 levels associated with ACS and CAD severity; hypothesis-generating, requires prospective validation before clinical use.
BACKGROUND: The previous studies have showed that serum retinol binding protein 4 (RBP4) levels increase in metabolic disorders which are closely associated with cardiovascular diseases (CVD). However, the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 with the presence and severity of coronary artery disease (CAD) in this study. METHODS: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study. The serum RBP4 concentrations were measured using ELISA method, clinically and anatomically score models were used to assess the severity of coronary lesion. RESULTS: Serum RBP4 levels were significantly higher in patients with ACS compared to the without ACS (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0.286 p = 0.034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score. CONCLUSIONS: The serum RBP4 levels increase in patients with CAD and its increased levels may be correlated with CAD severity.
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Nar et al. (2021) conducted a case-control in Acute Coronary Syndrome (ACS) / Coronary Artery Disease (CAD) (n=98). Serum retinol binding protein 4 (RBP4) levels vs. Control subjects with normal coronary arteries was evaluated on Serum RBP4 concentration (p=0.014). Serum RBP4 levels were significantly higher in patients with acute coronary syndrome compared to controls (68.40 vs 49.46 mg/L) and positively correlated with coronary artery disease severity scores.
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