Key result
Diabetes in ESRD fails to increase overall CAD prevalence but is linked to more triple-vessel disease.
Why the study?
The pattern and prevalence of coronary artery disease in non-diabetic patients with end stage renal disease are not well defined compared to diabetic patients.
Does diabetic status increase the prevalence of coronary artery disease in patients with end stage renal disease?
Population
158 consecutive patients with end stage renal disease (84 diabetic and 74 non-diabetic)
Comparison
Diabetic patients vs non-diabetic patients with end stage renal disease
Design
Observational study with coronary arteriography analysis
Authors
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Non-diabetic ESRD patients warrant coronary evaluation pre-transplant akin to diabetics; leaves open whether routine angiography improves transplant outcomes.
Observational (n=158)
Does diabetic status increase the prevalence of coronary artery disease in patients with end stage renal disease?
Absolute Event Rate: 67% vs 55%
p-value: p=0.15
Non-diabetic patients with end stage renal disease have a high prevalence of coronary artery disease comparable to diabetic patients, suggesting they may merit equally careful investigation of their coronary status.
Varghese et al. (2001) conducted an observational in End stage renal disease (n=158). Diabetes vs. Non-diabetic was evaluated on Prevalence of coronary artery disease (≥ 50% luminal diameter stenosis) (p=0.15). Diabetes in patients with end stage renal disease did not significantly increase overall coronary artery disease prevalence (67% vs 55%, p=0.15), but triple vessel disease was more common (27% vs 12%, p=0.005).
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