Why the study?
Does diabetes alter the angiographic severity and distribution of coronary artery disease or the frequency of left ventricular dysfunction in patients with CAD?
Does diabetes alter the angiographic severity and distribution of coronary artery disease or the frequency of left ventricular dysfunction in patients with CAD?
Diabetic patients with CAD exhibit more severe disease in intermediate segments and more frequent left ventricular dysfunction, which appears unrelated to the angiographic severity of CAD.
Diabetes may link to intermediate-segment stenoses and LV dysfunction in CAD; leaves open prognostic or therapeutic implications in observational data.
A comparison of data from 58 diabetic and 58 nondiabetic patients with arteriographic evidence of coronary artery disease showed that diabetic patients had a significantly greater frequency of major stenoses in the intermediate coronary artery segments but no significant differences in the proximal or distal segments. Thus, the diabetic patients did have more severe coronary disease, but the diabetic group did not have "more distal" disease as represented by the number of major or minor lesions in the distal segments. The diabetic patients had a significantly greater frequency of electrocardiographic intraventricular conduction defects and manifestations of left ventricular dysfunction. There was no significant difference in the severity of coronary artery disease between the diabetic patients with manifestations of myocardial decompensation and the diabetic patients without such manifestations, suggesting that the increased frequency of myocardial dysfunction in diabetic patients may be related to factors other than the greater severity of coronary artery disease.
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Wilson et al. (1983) studied this question.
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