Key result
COVID-19-related inflammatory illness linked to giant coronary aneurysms despite multi-agent immunomodulatory therapy.
Why the study?
The association of atypical Kawasaki-like illness and paediatric multisystem inflammatory syndrome with COVID-19 infection is highlighted by coronary artery aneurysms despite treatment.
Case Report (n=1)
This case highlights the risk of giant coronary artery aneurysms in infants with COVID-19-associated multisystem inflammatory syndrome (MIS-C) despite aggressive immunomodulatory therapy.
May warrant aneurysm surveillance in MIS-C infants; leaves Kawasaki-like overlap hypothesis-generating.
A 5-month-old female infant was admitted to hospital with a history of fever and rash during the recent coronavirus pandemic. She had significantly elevated inflammatory markers and the illness did not respond to first line broad spectrum antibiotics. The illness was later complicated by coronary artery aneurysms which were classified as giant despite treatment with intravenous immunoglobulin, steroids and immunomodulators. The infant had COVID-19 antibodies despite an initial negative COVID-19 PCR test. This case highlights the association of atypical Kawasaki like illness and paediatric multisystem inflammatory syndrome-temporarily associated with COVID-19 infection.
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Richardson et al. (2021) conducted a case report in Coronavirus-related inflammatory syndrome (n=1). COVID-19 infection was evaluated. A 5-month-old infant developed giant coronary artery aneurysms despite treatment, highlighting the association between atypical Kawasaki-like illness and COVID-19-related inflammatory syndrome.
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