Case report demonstrates clozapine-induced hypertension and elevated catecholamines in schizophrenia, suggesting the drug can trigger sympathetic hyperactivity.
OBJECTIVE: To report a case of clozapine-induced hypertension with raised urinary catecholamines. CLINICAL PICTURE: A 27-year-old man fulfilling DSM-III-R criteria for catatonic schizophrenia was treated with clozapine. He later developed both hypertension and raised urinary catecholamines which mimicked phaeochromocytoma. TREATMENT: Clozapine was withdrawn. OUTCOME: Both blood pressure and urinary catecholamines normalised. CONCLUSIONS: Clozapine may induce sympathetic hyperactivity.
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Li et al. (1997) studied this question.
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