Key result
T2DM is linked to increased oxidative stress markers and reduced antioxidant defenses vs healthy controls.
Why the study?
Oxidative stress is implicated in endothelial dysfunction in diabetes mellitus, but its role in the pathophysiology of diabetic cardiomyopathy requires investigation.
Are oxidative stress markers altered in patients with type 2 diabetes mellitus compared to healthy controls?
Case-Control (n=145)
Are oxidative stress markers altered in patients with type 2 diabetes mellitus compared to healthy controls?
Patients with type 2 diabetes exhibit significantly altered levels of oxidative stress markers, suggesting a potential pathophysiological role in diabetic cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Oxidative stress markers may associate with diabetic cardiomyopathy; leaves open causal role and need for prospective trials before clinical targeting.
Objectives Cardiovascular disease associated with diabetes remains the leading cause of morbidity and mortality worldwide. There is a growing scientific and public interest in connecting oxidative stress as a cause of endothelial dysfunction associated with pathological conditions such as diabetes mellitus (DM). Free radicals’ scavengers play a pivotal role in maintaining homeostasis. We investigated potential risk factors and the role of oxidative stress in the pathophysiology of diabetic cardiomyopathy. Patients and methods Eighty type 2 DM patients along with 65 normal healthy volunteers were recruited for this study. We calculated BMI, and measured arterial blood pressure. We measured glycosylated hemoglobin (HbA1C), lipid profile levels, catalase, nitric oxide, the enzymes superoxide dismutase, and malondialdehyde in plasma. Results We found that the mean BMI (32.63±3.42), HbA1C (8.07±1.39), malondialdehyde (1007.21±299.341), and nitric oxide (6.79±1.95) were significantly higher in the patient group compared with the control group. On the other hand, superoxide dismutase (2.97±0.69) and catalase (35.44±10.56) in diabetic patients were significantly lower compared with controls. Conclusion Our results confirm the role of oxidative stress in pathophysiology of DM. This suggests that antioxidants may have a putative therapeutic and a prognostic role in diabetic cardiomyopathy.
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Fathelbab et al. (2017) conducted a case-control in Type 2 Diabetes Mellitus (n=145). Type 2 Diabetes Mellitus vs. Normal healthy volunteers was evaluated on Oxidative stress markers (malondialdehyde, nitric oxide, superoxide dismutase, catalase).
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