Key result
A single i.p. injection of cisplatin (10 mg/kg) in mice significantly increased chemiluminescence and ATP contents of peritoneal exudate cells compared to untreated mice.
Cisplatin activates protein kinase-C and increases chemiluminescence and ATP content in mouse macrophages, suggesting an energy-dependent activation of NADPH-oxidase.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for cisplatin's macrophage activation in mice; clinical relevance and human translation remain undetermined.
A single i.p. injection of cisplatin (10 mg/kg body weight) into mice results in a significant increase in chemiluminescence and ATP contents of the peritoneal exudate cells (PEC) than that of PEC from untreated mice. It is also observed that in vitro treatment of macrophages with cisplatin, rIFN-gamma and LPS show increased activity of the protein kinase-C (PK-C). The activation of PK-C could result in stimulation of NADPH-oxidase resulting in increased levels of chemiluminescence. Increased contents of ATP in PEC after cisplatin treatment also suggests that this activation is energy dependent.
No takes yet. Share an insight, caveat, or question.
Sodhi et al. (1991) studied this question. Cisplatin vs. Untreated mice was evaluated on Chemiluminescence, ATP contents, and protein kinase-C activity. A single i.p. injection of cisplatin (10 mg/kg) in mice significantly increased chemiluminescence and ATP contents of peritoneal exudate cells compared to untreated mice.
Synapse has enriched 10 related papers. Consider them for comparative context: