Why the study?
The molecular basis of ionic remodeling in patients with atrial fibrillation was not well understood.
Observational
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Down-regulation of L-type calcium channel and KV4.3 potassium channel transcription levels underlies ionic remodeling in atrial fibrillation.
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张建成 et al. (2002) conducted an observational in Atrial fibrillation. Atrial fibrillation vs. Sinus rhythm was evaluated on mRNA expression of L-type voltage-dependent calcium channel alpha1c subunit, KV4.3 potassium channel alpha subunit, and voltage-dependent sodium channel alpha subunit (p=<0.05).
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