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Tc38 is an exclusively mitochondrial protein in Trypanosoma cruzi that shows dynamic localization during the cell cycle, supporting a role in kinetoplast DNA replication and maintenance.
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Tc38 merits exploration as a drug target in Chagas cardiomyopathy; leaves open validation and therapeutic translation.
Duhagon et al. (2009) studied Trypanosoma cruzi infection. Tc38 protein analysis was evaluated on Subcellular localization of Tc38 during the cell cycle. Tc38 is an exclusively mitochondrial protein in Trypanosoma cruzi that shows dynamic localization during the cell cycle, supporting a role in kinetoplast DNA replication and maintenance.
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