Key result
Neck irradiation (5,400 rads) for thyroid carcinoma resulted in the rare development of a tracheal malignant fibrous histiocytoma 11 years later.
Highlights a rare presentation of postirradiation malignant fibrous histiocytoma in the trachea.
Raises caution for rare late sarcomas after neck irradiation; leaves open incidence and risk stratification in survivors.
A 77-yr-old woman presented with a malignant fibrous histiocytoma (MFH) of the trachea 11 yr after right subtotal thyroidectomy and delivery of 5,400 rads to the neck for infiltrating papillary thyroid carcinoma. The tumor developed in the irradiated area. Postirradiation MFH tends to occur in subcutaneous tissues, and is rare in lung parenchyma or airways.
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Louie et al. (1987) studied this question. Neck irradiation (5,400 rads) for thyroid carcinoma resulted in the rare development of a tracheal malignant fibrous histiocytoma 11 years later.
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