Why the study?
Does external radiation therapy cause malignant fibrous histiocytoma in treated patients?
Does external radiation therapy cause malignant fibrous histiocytoma in treated patients?
Therapeutic irradiation is suggested as a causative factor for malignant fibrous histiocytoma, presenting after a 3 to 17 year latent period.
These cases suggest radiation may cause late MFH; the association remains hypothesis-generating and should not change practice.
Five patients who were successfully treated with external radiation therapy for a variety of histologically unrelated tumors subsequently developed malignant fibrous histiocytoma (MFH) within the irradiated field. It is suggested that therapeutic irradiation was a causative factor in the development of these tumors with latent periods ranging between 3 and 17 years. A review of the pertinent literature is presented. It is apparent that postradiation MFH is being recognized with increasing frequency and at an earlier age than when it appears de novo.
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Amendola et al. (1985) studied this question.
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