Highlights the risk of developing malignant fibrous histiocytoma as a late complication within irradiated fields following radiation therapy for primary cancers.
MFH may arise years after radiation; case reports leave open incidence, risk factors, and surveillance needs.
Three patients who were treated successfully with postoperative external radiation therapy for ovarian carcinoma, endometrial adenocarcinoma and bilateral retinoblastoma respectively developed years later malignant fibrous histiocytoma (MFH) within the irradiated field. MFH is a recently described soft tissue sarcoma known for its dual fibroblastic and histiocytic differentiation resulting in a pleomorphic histologic appearance.
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Tewfik et al. (1981) studied this question.
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