Key result
Normal-weight smokers show similarly elevated hs-CRP levels as obese nonsmokers in impaired glucose tolerance.
Why the study?
Impaired glucose tolerance is associated with increased cardiovascular disease risk, but the relationship of hs-CRP levels in IGT smokers with normal body weight versus obese nonsmokers is not well understood.
Do hs-CRP levels differ between regular body weight smokers with IGT and obese non-smokers with IGT?
Cross-Sectional (n=40)
No
Do hs-CRP levels differ between regular body weight smokers with IGT and obese non-smokers with IGT?
Absolute Event Rate: 3.55% vs 4.13%
p-value: p=>0.1
Both regular body weight smokers and obese non-smokers with impaired glucose tolerance have moderately high levels of hs-CRP, indicating high cardiovascular risk, with no significant difference between the two groups.
Background: Impaired glucose tolerance (IGT) is associated with an increased cardiovascular diseaserisk. Less is known about cardiovascular disease risk among subjects with impaired fasting glucose(IFG). Metabolic diseases are affecting human health all over the world. These chronic subclinicaldisease states are associated with highly sensitive CRP. Objective: The present study aims to measurehs-CRP as a marker in adult IGT (impaired glucose tolerance) patients explore its relationship tosmoking of normal body weight person and obesity of non smoker person to compere and predict thehigher risk group for future development of CVD and diabetes. Methodology: A total of 40 adults, age30-60 years, healthy IGT subjects were recruited in this study. We were taken the measurement of bloodglucose, hs-CRP levels, BMI and smoking history. Statistical Package for Social Program (SPSS) wasused for data analysis by using Windows version 17. Results were expressed as mean±SD. Student’s ‘t’test was done to see the difference, and p <0.05 was considered significant. Results: The mean BMI ofgroup I was 22.1±2.3, and group II was 33.3±2.5, indicating strong statistical significance. The meanand average serum levels of hs-CRP in smoker IGT and obese IGT subjects were 3.55±1.46 (0.39- 3.68)and 4.13±1.63 (0.48-4.4) mg/L, respectively, with a cut-off value of 3mg/l. The total 40 subjects hadhs-CRP above the cutoff value. Hs-CRP was almost similarly high in both groups. However, there isno significant difference between IGT smokers (with normal body weight) and IGT obese (nonsmoker)subjects. Conclusion: The prevalence of risk factors for CVDs and diabetes is high in Bangladesh.In this study, all IGT regular body weight smoker patients and IGT obese nonsmoker patients havemoderately high levels of hs-CRP. Therefore, both the IGT regular body weight smoker group and theIGT obese nonsmoker group were in the high-risk group. However, here, IGT smokers and the IGTobese group did not significantly differ from each other as a higher high-risk group.
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Fahmi et al. (2025) conducted a cross-sectional in Impaired glucose tolerance (n=40). Normal body weight smoking vs. Obesity (nonsmoker) was evaluated on Serum hs-CRP levels (mg/L) (p=>0.1). Normal-weight smokers and obese nonsmokers with impaired glucose tolerance both exhibited moderately high hs-CRP levels (3.55 mg/L vs 4.13 mg/L), with no significant difference between the groups.
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