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May 15, 2023Clinical NutritionOpen Access

Among 204 individuals with type 2 diabetes, higher plasma concentrations of total carotene were associated with a lesser atherosclerotic plaque burden, remaining significant only in women.

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Why the study?

Are higher plasma carotene concentrations associated with reduced atherosclerotic plaque burden in newly diagnosed type 2 diabetic individuals?

Population

204 participants from the DIABIMCAP cohort (newly diagnosed type 2 diabetic individuals)

Comparison

Higher plasma concentrations of total, α-, and… vs Lower plasma concentrations of carotenes

Design

Cross-sectional

Key result

Among 204 individuals with type 2 diabetes, higher plasma concentrations of total carotene were associated with a lesser atherosclerotic plaque burden, remaining significant only in women.

Authors

FBFrancesc BujosaZHZoe HerrerasMCMarta Catalán

Discussion

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Member takes

Overview

Higher carotene levels inversely associated with plaque burden; hypothesis-generating for fruit/vegetable-rich diets attenuating atherosclerosis, needs prospective confirmation.

Study Design

Type

Cross-Sectional (n=204)

Structured PICO

Are higher plasma carotene concentrations associated with reduced atherosclerotic plaque burden in newly diagnosed type 2 diabetic individuals?

P
Population
204 newly diagnosed type 2 diabetic individuals evaluated for the association between carotene plasma concentrations and atherosclerotic burden.
E
Exposure
Higher plasma concentrations of total, α-, and β-carotenes (surrogate for fruit and vegetable intake)
C
Comparator
Lower plasma concentrations of carotenes
O
Outcome
Atherosclerotic burden and intima media thickness (IMT) measured by carotid ultrasoundsurrogate

Higher plasma carotene concentrations, reflecting a diet rich in fruits and vegetables, are inversely associated with atherosclerotic plaque burden, particularly in women with newly diagnosed type 2 diabetes.

Cite This Study

Bujosa et al. (2023) conducted a cross-sectional in Type 2 Diabetes (n=204). Total carotene plasma concentrations vs. Lower carotene plasma concentrations was evaluated on Atherosclerotic plaque burden. Among 204 individuals with type 2 diabetes, higher plasma concentrations of total carotene were associated with a lesser atherosclerotic plaque burden, remaining significant only in women.

synapsesocial.com/papers/6ab5ca78d08a8bcc49563e67https://doi.org/10.1016/j.clnu.2023.05.005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study2003 · 132 citations
  2. 2Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima–Media Thickness: A Systematic Review and Meta-Analysis2026
  3. 3Higher dietary and serum carotenoid levels are associated with lower carotid intima–media thickness in middle-aged and elderly people2018 · 20 citations
  4. 4Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness2020 · 29 citations
  5. 5Relationship between Plasma Lipidomics and Carotid Atherosclerotic Plaque2020