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December 2, 2003Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study

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Why the study?

Are higher baseline plasma levels of oxygenated and hydrocarbon carotenoids associated with reduced progression of carotid intima-media thickness in middle-aged adults free of cardiovascular disease?

Population

573 middle-aged women and men from an occupational cohort, free of symptomatic cardiovascular disease at…

Comparison

Higher baseline plasma levels of oxygenated… vs Lower baseline plasma levels of these antioxidants

Design

Cohort

Follow-up

18 months

Authors

JDJames H. DwyerMPMaura Paul‐LabradorJFJing Fan

Discussion

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Overview

Supports dietary carotenoid benefits for vascular health in primary prevention; extends observational data but leaves causal effects on IMT open.

Structured PICO

Are higher baseline plasma levels of oxygenated and hydrocarbon carotenoids associated with reduced progression of carotid intima-media thickness in middle-aged adults free of cardiovascular disease?

P
Population
573 middle-aged women and men from an occupational cohort, free of symptomatic cardiovascular disease at baseline
I
Intervention
Higher baseline plasma levels of oxygenated carotenoids (lutein, beta-cryptoxanthin, zeaxanthin) and hydrocarbon carotenoids (alpha-carotene)
C
Comparator
Lower baseline plasma levels of these antioxidants
O
Outcome
Change in carotid intima-media thickness (IMT) at 18-month follow-upsurrogate

Higher plasma levels of oxygenated carotenoids and alpha-carotene are associated with reduced progression of early atherosclerosis as measured by carotid IMT.

Cite This Study

Dwyer et al. (2003) studied this question.

synapsesocial.com/papers/6a8aa4996fc170cbc2fc04cahttps://doi.org/10.1161/01.atv.0000109955.80818.8a
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort2023 · 5 citations
  2. 2Plasma Antioxidants and Asymptomatic Carotid Atherosclerotic Disease2008 · 31 citations
  3. 3Circulating Lycopene and β-Carotene Levels Are Inversely Associated with Carotid Intima–Media Thickness: A Systematic Review and Meta-Analysis2026
  4. 4Higher dietary and serum carotenoid levels are associated with lower carotid intima–media thickness in middle-aged and elderly people2018 · 20 citations
  5. 5Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers2003 · 141 citations