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January 1, 2008Annals of Nutrition and Metabolism

Plasma Antioxidants and Asymptomatic Carotid Atherosclerotic Disease

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Why the study?

Are low plasma concentrations of antioxidant vitamins and lycopene associated with early carotid atherosclerotic lesions?

Population

Individuals assessed for asymptomatic carotid atherosclerotic disease

Design

Cross-sectional

Authors

GRGraziano RiccioniTBTonino BucciarelliNDNicolantonio D’Orazio

Discussion

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Overview

Does not support antioxidant supplementation; leaves open causal effects on carotid atherosclerosis progression.

Structured PICO

Are low plasma concentrations of antioxidant vitamins and lycopene associated with early carotid atherosclerotic lesions?

P
Population
Individuals assessed for asymptomatic carotid atherosclerotic disease
I
Intervention
Low plasma concentrations of antioxidant vitamins (A, E, beta-carotene) and lycopene
O
Outcome
Early carotid atherosclerotic lesions as measured by CIMTsurrogate

Low plasma levels of antioxidant vitamins and lycopene are associated with increased carotid intima-media thickness, suggesting a potential role for dietary antioxidants in slowing atherosclerosis progression.

Cite This Study

Riccioni et al. (2008) studied this question.

synapsesocial.com/papers/69d56eef75589c71d767d7d5https://doi.org/10.1159/000164691
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study2003 · 132 citations
  2. 2Circulating Plasma Antioxidants, Inflammatory Markers and Asymptomatic Carotid Atherosclerosis in End-Stage Renal Disease Patients: A Case Control Study2010 · 13 citations
  3. 3Relationship between plasma antioxidant concentrations and carotid intima-media thickness: the Asymptomatic Carotid Atherosclerotic Disease In Manfredonia Study2009 · 58 citations
  4. 4Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort2023 · 5 citations
  5. 5Plasma carotenoids are related to intima - media thickness of the carotid artery wall in men from eastern Finland2011 · 32 citations