Key result
Longer post-implant TpTe linked to ~2% higher risk of appropriate ICD therapy.
Why the study?
The ability of Tpeak-Tend interval (TpTe) to predict ventricular tachyarrhythmia and mortality in heart failure patients with an implantable cardioverter-defibrillator (ICD) was not clear.
Does a prolonged Tpeak-Tend interval predict appropriate ICD therapy and mortality in heart failure patients with an implantable cardioverter-defibrillator?
Cohort (n=318)
Does a prolonged Tpeak-Tend interval predict appropriate ICD therapy and mortality in heart failure patients with an implantable cardioverter-defibrillator?
Hazard Ratio: 1.017 (95% CI 1.008–1.026)
Absolute Event Rate: 45% vs 11.3%
p-value: p=<.001
Post-implantation Tpeak-Tend interval is an independent predictor of ventricular arrhythmias and all-cause mortality in heart failure patients with an ICD, offering a potential non-invasive marker for risk stratification.
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TpTe may aid arrhythmia risk stratification in HF-ICD patients; leaves open incremental value over existing predictors.
Xue et al. (2019) conducted a cohort in heart failure with an implantable cardioverter-defibrillator (n=318). Tpeak-Tend interval (TpTe) > 110 ms vs. TpTe < 90 ms was evaluated on appropriate ICD therapy (VT/VF episodes) (HR 1.017, 95% CI 1.008-1.026, p=<.001). Longer post-implantation Tpeak-Tend interval was associated with an increased risk of appropriate ICD therapy for VT/VF episodes (HR 1.017; 95% CI 1.008-1.026; P<0.001).
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